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في تصنيف التعليم بواسطة (17.8ألف نقاط)

تكملة في جرعات الاطفال - كلية الطب

 


الاجابة


ال ceftazidime واحد من أدويه الجيل التالت لعيلة ال cephalospotin 

اللي بيشتغل كويس ع gram  negative وخاصة ع 

Pseudomonas

طيب نشوف شو ال Indication اله وجرعاته بالأطفال ‍♀

1⃣General dosing, susceptible infection (IM, IV: Infants, Children, and Adolescents) 

️ Non-Pseudomonas spp. infections: 

90 to 150 mg/kg/day divided every 8 hours; maximum daily dose: 6 g/day.

️Pseudomonas spp. infections:

Mild to moderate infections: 90 to 150 mg/kg/day divided every 8 hours; maximum daily dose: 6 g/day.

Severe infections: 200 to 300 mg/kg/day divided every 8 hours; maximum daily dose: 12 g/day.

2⃣Cystic fibrosis, lung infection caused by Pseudomonas spp. or other susceptible gram negative organisms

Traditional intermittent infusion method:

Infants, Children, and Adolescents: IV: 200 to 400 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 12 g/day

Continuous infusion method:

Children ≥5 years and Adolescents: IV: 100 to 200 mg/kg/day infused continuously over 24 hours; maximum daily dose: 12 g/day

لو كانت الحالة  sepsis يُفضل اعطاء loading dose قبل ال 

Continuous infusion 

initial loading dose (60 mg/kg; maximum dose: 2,000 mg/dose) once before starting the continuous infusion

3⃣Endocarditis, treatment: Children and Adolescents:

 IV: 100 to 150 mg/kg/day divided every 8 hours

 (maximum daily dose: 4,000 mg/day)

use in combination with gentamicin or vancomycin and gentamicin (plus rifampin if prosthetic material is present) depending on the cause of infection.

4⃣Intra-abdominal infections, complicated: Infants, Children, and Adolescents: IV: 50 mg/kg/dose every 8 hours in combination with metronidazole; maximum daily dose: 6 g/day

5⃣Meningitis, including healthcare-associated ventriculitis/meningitis:

 Infants, Children, and Adolescents:

 IV: 150 to 200 mg/kg/day in divided doses every 8 hours; maximum daily dose: 6 g/day; use in combination with vancomycin for empiric coverage

6⃣Urinary tract infection: Infants, Children, and Adolescents: 

IV: 100 to 150 mg/kg/day divided every 8 hours 

لو كان الطفل عنده مشاكل بالكلى وال serum creatinine اعلى من الطبيعي بنعدل الجرعه حسب قيم ال GFR 

Renally adjusted dose recommendations are based on a usual dose of 25 to 50 mg/kg/dose every 8 hours

1⃣GFR >50 mL/minute/1.73 m2: No adjustment required.

2⃣GFR 30 to 50 mL/minute/1.73 m2: 50 mg/kg/dose 

every 12 hours.

3⃣GFR 10 to 29 mL/minute/1.73 m2: 50 mg/kg/dose every 24 hours.

 4⃣GFR <10 mL/minute/1.73 m2: 50 mg/kg/dose every 48 hours.

 5⃣Hemodialysis: Dialyzable (50% to 100%): 50 mg/kg/dose every 48 hours, give after dialysis on dialysis days.

 6⃣Peritoneal dialysis: 50 mg/kg/dose every 48 hours.

 7⃣Continuous renal replacement therapy (CRRT): 50 mg/kg/dose every 12 hours

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تكملة في جرعات الاطفال - كلية الطب

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